Poster Session-Wednesday, April 04, 2007

Poster Session-Wednesday, April 04, 2007

08:30 am – 05:00 pm

Poster Session

P- 70

FERRITIN ENDOCYTOSIS IN CACO-2 CELLS, A GUT IRON ABSORPTION MODEL, IS MEDIATED BY ASSEMBLY PEPTIDE-2.

C. SanMartin, PhD(candidate), C. Garri, PhD (candidate), F. Pizarro, PhD, T. Walter, MD, E. Theil, PhD and M. Nunez, PhD, Biology, Faculty of Sciences, University of Chile (Presented By: M. Nunez, PhD)

P- 71

REGULATION OF INTESTINAL HEME ABSORPTION IN HFE-KNOCK OUT AND HPX MICE.

A. Laftah, PhD, G. Latunde-Dada, PhD, R. Simpson, PhD, S. Fakih, PhD, R. Hider, Prof and A. Mckie, Prof, King’s College London (Presented By: A. Laftah, PhD)

P- 72

FERRITIN – A NOVEL MECHANISM FOR DELIVERY OF IRON TO THE BRAIN AND OTHER ORGANS.

J. Connor, PhD, J. Fisher, K. Devraj, J. Ingram, B. Slagle-Webb, A. Madhankumar, PhD, M. Klinger and I. Simpson, PhD, Pennsylvania State University College of Medicine (Presented By: J. Connor, PhD)

P- 73

TRANSFERRIN RECEPTOR INTERACTION INVESTIGATED BY ATOMIC FORCE
MICROSCOPY

A. Yersin, A. Ikai, Tokyo Institute of Technology (Presented By: A. Yersin)

P- 74

TRANSFERRIN RECEPTOR 2 EXPRESSION AND IRON UPTAKE IN HUMAN HEPATOMA CELLS

C. Herbison, BSc(Hons), K. Thorstensen, PhD, R. Graham, PhD, A. Chua, PhD, J. Olynyk, MBBS MD and D. Trinder, PhD, University of Western Australia (Presented By: C. Herbison,

P- 75

ROLE OF DCYTB IN DUODENAL IRON ABSORPTION

J. Choi, Y. Latunda-dada, PhD, A. McKie, PhD and R. Simpson, PhD, King’s College London (Presented By: J. Choi)

P- 76

INCREASED SERUM TRANSFERRIN LEVELS IN CHRONIC HEPATITIS C

K. Taketa, MD, Brain Attack Center Oota Memorial Hospital (Presented By: K. Taketa, MD)

P- 77

HIGH-RESOLUTION STRUCTURES OF HUMAN H-CHAIN APOFERRITINS CORRELATED
WITH THEIR ACTIVITY AND METAL-BINDING SITES

R. Crichton, PhD FRSC, L. Toussaint, PhD, L. Bertrand, MD, L. Hue, MD DPhil and J. Declercq, PhD, University of Louvain (Presented By: R. Crichton, PhD FRSC)

P- 78

THE ROLE OF LYSOSOMAL LABILE IRON POOL IN DIFFERENTIAL SENSITIVITY OF JURKAT T CELL LINES TO HYDROGEN PEROXIDE

A. Al-Qenaei, MPhil, A. Yiakouvaki, PhD, N. Hall, PhD and C. Pourzand, PhD, University of Bath (Presented By: A. Al-Qenaei, MPhil)

P- 79

RECIPROCAL RELATIONSHIP BETWEEN CIRCULATING GASTRIN AND IRON STATUS IN MICE AND HUMANS.

G. Baldwin, PhD, DSc, K. Smith, PhD, S. Kovac, BSc (Hons), G. Anderson, PhD, J. Burgess, MB, BS and A. Shulkes, PhD, DSc, University of Melbourne (Presented By: G. Baldwin, PhD,

P- 80

EXTENSIVE EXCESS CAPACITY OF THE IRP SYSTEM IN CELLULAR IRON REGULATION

W. Wang, X. Di, S. Torti, PhD and F. Torti, MD, Wake Forest University (Presented By: F. Torti, MD)

P- 81

ANALYSIS OF THE REGULATION OF THE HFE EXPRESSION IN STABLY TRANSFECTED CELLS

C. Mura, PhD, P. Ding and C. Ferec, UBO, INSERM U613 (Presented By: C. Mura, PhD)

P- 82

TRANSCRIPTIONAL REGULATION OF THE HEPCIDIN GENE BY UPSTREAM STIMULATORY FACTOR AND C-MYC/MAX

K. Srai, BSc (Hons), PhD, H. McArdle, PhD and H. Bayele, PhD, Department of Biochemistry & Molecular Biology (Presented By: K. Srai, BSc (Hons), PhD)

P- 83

CHARACTERIZATION OF MAMMALIAN AND BACTERIAL SIDEROPHORES

K. Mori, MD, PhD, M. Mukoyama, MD, PhD, T. Kuwabara, MD, A. Kalandadze, MD, J. Li, PhD, N. Paragas, K. Nakao, MD, PhD and J. Barasch, MD, PhD, Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine (Presented By: K. Mori, MD,

P- 84

CHARACTERIZATION OF A LOW MOLECULAR WEIGHT IRON COMPONENT THAT MAY BE A PART OF THE LABILE IRON POOL

M. Linder, PhD, B. Rojas, BS, L. Planutyte, BS, V. Thon, BS, C. Gilley, BS, C. Srinivasan, PhD and N. Rangel, BS, California State University (Presented By: M. Linder, PhD)

P- 85

ANALYSIS OF THE STRUCTURAL REQUIREMENTS FOR RECYCLING ENDOSOME-TARGETING OF DMT1 ISOFORM II.

M. Tabuchi, PhD, I. Yanatori, DDS and F. Kishi, MD, PhD, Kagoshima University (Presented By: M. Tabuchi, PhD)

P- 86

PURIFICATION, FUNCTION AND TISSUE DISTRIBUTION OF FERRITIN BINDING PROTEIN (FBP)

M. Akita, PhD, T. Abe, M. Inoue, DDS and K. Setsu, MD, PhD, Tokushima Bunri University (Presented By: M. Akita, PhD)

P- 87

HEPCIDIN SUPPRESSION BY ERYTHROPOIESIS DOMINATES OVER STIMULATION BY INFLAMMATION IN A MOUSE MODEL OF PERITONITIS

S. Lasocki, MD, P. Letteron, PhD, V. Andrieu, MD, O. Thibaudeau, P. Montravers, MD, PhD and C. Beaumont, PhD, INSERM U773, CRB3, Universite Paris 7, site Bichat (Presented By: C. Beaumont, PhD)

P- 88

ALCOHOL SUPPRESSES THE IRON-INDUCED REGULATION OF HEPCIDIN TRANSCRIPTION IN VIVO

D. Harrison-Findik, E. Klein, C. Crist and J. Gollan, Department of Medicine, University of Nebraska Medical Center (Presented By: D. Harrison-Findik)

P- 89

MEASUREMENT OF URINARY HEPCIDIN LEVELS BY SELDI-TOF-MS IN HFE-HEMOCHROMATOSIS.

D. Girelli, MD, PhD, C. Bozzini, MD, E. Nemeth, PhD, A. Castagna, PhD, N. Campostrini, PhD, A. Bossi, PhD, R. Corrocher, MD, C. Camaschella, MD, A. Piperno, MD, T. Ganz, MD, PhD and O. Olivieri, MD, Department of Clinical and Experimental Medicine (Presented By: D. Girelli, MD, PhD)

P- 90

MASS SPECTROMETRY-BASED HEPCIDIN MEASUREMENTS IN SERUM AND URINE: ANALYTICAL ASPECTS AND CLINICAL IMPLICATIONS

E. Kemna, MSc, H. Tjalsma, PhD, V. Podust, PhD and D. Swinkels, PhD, Dept. of Clinical Chemistry, Radboud University Nijmegen Medical Centre (Presented By: E. Kemna, MSc)

P- 91

THE REGULATION AND ROLE OF MACROPHAGE HEPCIDIN DURING INFLAMMATION AND IN ACD PATIENTS

I. Theurl, M. Theurl, H. Niederegger, S. Mair, M. Seifert and G. Weiss, Medical University, Department of General Internal Medicine (Presented By: G. Weiss)

P- 92

CORRELATION BETWEEN PROHEPCIDIN LEVEL AND IRON PARAMETER IN INFANT PATIENTS WITH IRON DEFICIENCY ANEMIA AND ANEMIA-FREE INFANTS WITH ACUTE INFECTION

J. Lim, Gyeongsang National University College of Medicine (Presented By: J. Lim)

P- 93

EFFECT OF PHLEBOTOMY ON THE EXPRESSION OF HEPCIDIN GENES IN MALE AND FEMALE HEMOJUVELIN-MUTANT MICE

J. Krijt, PhD, V. Niederkofler, PhD, R. Salie, PhD, M. Vokurka, MD, PhD and E. Necas, Prof, MD, PhD, Institute of Pathophysiology, First Faculty of Medicine, Charles University (Presented By: J. Krijt, PhD)

P- 94

THE SERUM LEVEL OF HEPCIDIN AFTER STEM CELL TRANSPLANTATION

J. Kanda, MD, C. Mizumoto, MD, H. Kawabata, MD, N. Tomosugi, MD and T. Uchiyama, MD, Kyoto University (Presented By: J. Kanda, MD)

P- 95

MOUSE HEPATOCYTES AND RAT LIVER EPITHELIAL CELLS COCULTURE: A PROMISING ORIGINAL MODEL FOR STUDYING THE REGULATION OF HEPCIDIN GENE

N. Fatih, PhD student, E. Camberlein, PhD student, A. Corlu, PhD, E. Abgueguen, PhD, P. Leroyer, P. Brissot, MD and O. Loreal, MD, PhD, INSERM U522, IFR140, University of Rennes 1 (Presented By: N. Fatih, PhD student)

P- 96

ABNORMAL EXPRESSION OF HEPCIDIN DURING GENETIC HEMOCHROMATOSIS, ALCOHOLIC CIRRHOSIS AND DYSMETABOLIC HEPATOSIDEROSIS.

O. Loreal, MD, PhD, E. Nemeth, PhD, C. Le Lan, MD, C. Jung, PhD, M. Ropert, MD, M. Troadec, PhD, L. Detivaud, PhD, C. Jard, MD, M. Pouchard, MD, A. Le Treut, MD, Y. Deugnier, MD, T. Ganz, MD, PhD and P. Brissot, MD, INSERM U522, IFR 140, University of Rennes (Presented By: O. Loreal, MD, PhD)

P- 97

DEFECTIVE TARGETING OF HEMOJUVELIN TO PLASMA MEMBRANE IS A COMMON PATHOGENETIC MECHANISM IN JUVENILE HEMOCHROMATOSIS

L. Silvestri, A. Pagani, C. Fazi, G. Gerardi, S. Levi, P. Arosio and C. Camaschella, MD, Vita-Salute San Raffaele University (Presented By: C. Camaschella, MD)

P- 98

EXPRESSION AND REGULATION OF HCP1 AND ABCG2 IN MICE TISSUES AND HUMAN CULTURED CELLS

G. Latunde-Dada, PhD, A. Lafthah, PhD, M. Shayeghi, PhD, R. Simpson, PhD and A. McKie, PhD, Kings College, London (Presented By: G. Latunde-Dada, PhD)

P- 99

VDAC2 AND ALDOLASE A IDENTIFIED AS MEMBRANE PROTEINS UPREGULATED UNDER IRON DEPRIVATION: POSSIBLE INVOLVEMENT IN NON-TRANSFERRIN IRON UPTAKE

J. Kovar, DSc, K. Valis, J. Neubauerova, P. Man, PhD, P. Pompach and J. Vohradsky, PhD, Third Faculty of Medicine, Charles University (Presented By: J. Kovar, DSc)

P- 100

GENETIC BACKGROUND, DIURNAL CYCLE, AND DIET ALL CONTRIBUTE TO VARIATIONS IN SYSTEMIC AND BRAIN IRON STATUS

J. Beard, PhD, B. Jones, PhD, L. Jones, BS, E. Unger, PhD, L. Bianco, BS, S. Rundle, MS, J. Connor, PhD, R. Allen, PhD and C. Earley, MD, PhD, Department of Nutritional Science, Penn State University (Presented By: J. Beard, PhD)

P- 101

EXPRESSION PROFILE OF HEALTHY ERYTHROID PROGENITORS

A. Merryweather-Clarke, PhD, A. Atzberger, H. Shah, H. Woffendin, S. Soneji, C. Waugh, K. Clark, J. Brown, J. Sloane-Stanley, W. Wood, T. Freeman, D. Higgs, V. Buckle and K. Robson, MRC Molecular Haematology Unit (Presented By: A. Merryweather-Clarke, PhD)

P- 102

CELLULAR EVIDENCES OF HEME CATABOLISM OUTSIDE THE ERYTHROPHAGOLYSOSOME

F. Canonne-Hergaux, PhD, C. Rondeau, Technician, C. Pouzet, PhD, C. Delaby, PhD, N. Pilard, Technician and M. Desjardins, PhD, INSERM-CNRS (Presented By: F.

P- 103

MARGINAL IRON SUPPLEMENTATION: POTENTIAL HAZARDS INVESTIGATED

R. Ward, PhD, R. Crichton, PhD, M. McHugh, PhD, S. Singh Srai, PhD and K. Summer, PhD, University of Louvain (Presented By: R. Ward, PhD)

P- 104

REGULATION OF HEPCIDIN EXPRESSION BY IRON AND ERYTHROPOIETIN DESPITE FUNCTIONAL LOSS OF TRANSFERRIN RECEPTOR 2

R. Fleming, MD, H. Morgan, MD, R. Britton, PhD, M. Migas, MS, G. Palmer, BS, R. O’Neill, BS, W. Sly, MD and B. Bacon, MD, Saint Louis University School of Medicine (Presented By: R. Fleming, MD)

P- 105

ALTERED IRON HOMEOSTASIS AS AN UNDERLYING MECHANISM OF ANGIOTENSIN II-INDUCED CARDIOVASCULAR DAMAGE.

N. Ishizaka, K. Saito, MD, K. Furuta, G. Matsuzaki, MD and R. Nagai, MD, University of Tokyo Graduate School of Medicine (Presented By: N. Ishizaka)

P- 106

CELLULAR IRON STATUS INFLUENCES THE FUNCTIONAL RELATIONSHIP BETWEEN MICROGLIA AND OLIGODENDROCYTES

J. Connor, PhD, X. Zhang, PhD, N. Surguladze, PhD, B. Slagle-Webb and A. Cozzi, PhD, Pennsylvania State University College of Medicine (Presented By: J. Connor, PhD)

P- 107

CYTOKINE REGULATION OF IRON HOMEOSTASIS PROTEINS IN MAMMALIAN GLIAL CELLS IN VITRO

K. Rathore and S. David, PhD, Centre for Research In Neuroscience, McGill University Health Center, Montreal (Presented By: K. Rathore)

P- 108

IRON TRANSPORT BY RAT PROXIMAL COLON IN ANIMALS FED AN IRON LOADED DIET

K. Johnston, PhD, J. Marks, PhD, S. Srai, PhD, E. Debnam, PhD and P. Sharp, PhD, King’s College London (Presented By: P. Sharp, PhD)

P- 109

SERUM FERRITIN AND TRANSFERRIN SATURATION IN ASIANS AND PACIFIC ISLANDERS LIVING IN THE U.S. AND CANADA: THE HEMOCHROMATOSIS AND IRON OVERLOAD SCREENING (HEIRS) STUDY

C. McLaren, PhD, E. Harris, PhD, D. Reboussin, PhD, V. Gordeuk, MD, J. Barton, MD, R. Acton, PhD, G. McLaren, MD, T. Vogt, MD, B. Snively, PhD, C. Leiendecker-Foster, MS, J. Holup, MA, L. Passmore, MS, J. Eckfeldt, MD, PhD, E. Lin, MD, FRCP (C) and P. Adams, MD, University of California, Irvine (Presented By: C. McLaren, PhD)

P- 110

SKIN IN HEREDITARY HEMOCHROMATOSIS

A. del Castillo-Rueda, P. de la Cueva-Dobao, P. Zamberk-Majlis, M. Solas-Alados and L. Alvarez-Sala-Walther, Unidad de Ferropatologia y Radicalosis. Hospital General Universitario Gregorio Maranon. Madrid. Spain (Presented By: A. del Castillo-Rueda)

P- 111

A PROBABLE CASE OF COEXISTENT HEMOCHROMATOSIS AND CELIAC DISEASE

C. Whittington, MB BS and M. Newton, MB ChB, University of British Columbia (Presented By: C. Whittington, MB BS)

P- 112

FIRST-DEGREE RELATIVES OF C282Y HOMOZYGOUS PROBANDS WITH CLINICALLY DETECTED HEMOCHROMATOSIS HAVE INCREASED MORBIDITY COMPARED TO THE GENERAL POPULATION. THE HEMOCHROMATOSIS FAMILY STUDY (HEFAS)

E. Jacobs, MD, J. Hendriks, PhD, J. Marx, MD, PhD, C. van Deursen, MD, PhD, H. Kreeftenberg, MD, PhD, R. de Vries, MD, PhD, A. Stalenhoef, MD, PhD, A. Verbeek, MD, PhD and D. Swinkels, MD, PhD, Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Center (Presented By: D. Swinkels, MD, PhD)

P- 113

HOMOZYGOSITY FOR THE C282Y MUTATION IN THE HFE GENE IS ASSOCIATED WITH INCREASED RISK OF COLORECTAL AND BREAST CANCER IN AUSTRALIAN POPULATION

N. Osborne, MAgSci PhD, L. Gurrin, PhD, K. Allen, MBBS PhD, C. Constantine, PhD, M. Delatycki, MBBS PhD, A. Nisselle, BSc, A. Fletcher, MEpi, C. McLaren, MS PhD, D. English, PhD, J. Hopper, PhD, G. Giles, PhD, J. Olynyk, MBBS, A. Nicoll, MBBS, L. Powell, MBBS and D. Gertig, MBBS MHSc ScD, University of Melbourne (Presented By: N. Osborne, MAgSci

P- 114

NON-FASTING SERUM TRANSFERRIN SATURATION (TS) IS SIMILAR TO FASTING TS FOR THE DETECTION OF C282Y HOMOZYGOTES FOR HEMOCHROMATOSIS

P. Adams, MD, D. Reboussin, PhD, R. Press, MD, J. Barton, MD, R. Acton, PhD, G. Moses, PhD, C. Leiendecker-Foster, MS, G. McLaren, MD, F. Dawkins, MD, V. Gordeuk, MD, L. Lovato, MS and J. Eckfeldt, MD, Phd, University Hospital (Presented By: P. Adams, MD)

P- 115

A LATE-ONSET JUVENILE HAEMOCHROMATOSIS DUE TO L194R/C347XCOMPOUND HETEROZYGOSITY OF HEMOJUVELIN IN A FRENCH FAMILY

J. ROCHETTE, I. FAJARDY, K. FOULON, MSc, E. VERLET, MD, P. DANZE, MD and E. CADET, PharmD, PHD, Medical School/University Hospital (Presented By: J. ROCHETTE)

P- 116

GRACILE SYNDROME- COMPLEX III DEFICIENCY WITH IRON OVERLOAD

P. Leveen, PhD, H. Kotarsky, PhD, R. Karikoski, MD, D. Zhang, PhD and V. Fellman, MD, PhD, Department of Pediatrics (Presented By: P. Leveen, PhD)

P- 117

REDUCED HEME SYNTHESIS DURING TERMINAL DIFFERENTIATION OF PRIMARY ERYTHROID CELLS ISOLATED FROM FRIEDREICH’S ATAXIA PATIENTS

C. Leberbauer, M. Schifrer, M. Schranzhofer, B. Sturm, B. Scheiber-Mojdehkar and E. Mullner, Medical University of Vienna, Department of Medical Biochemistry (Presented By: C.

P- 118

HEPATIC HEPCIDIN MRNA IS DECREASED IN THALASSEMIA: A STUDY OF 23 PATIENTS.

E. Camberlein, PhD student, G. Zanninelli, MD, PhD, L. Detivaud, PhD, A. Lizzi, F. Sorrentino, MD, S. Vacquer, MD, E. Angelucci, MD, O. Loreal, MD, PhD, P. Cianciulli, MD, M. Lai, MD and P. Brissot, MD, INSERM U522, IFR140, University of Rennes 1 (Presented By: E. Camberlein, PhD student)

P- 119

EXPRESSION OF HAEMOCHROMATOSIS-ASSOCIATED GENES IN THE ZEBRAFISH

C. Lok, BSc (Hons), A. Merryweather-Clarke, K. Brakspear, P. Pinheiro, L. Patterson, R. Patient and K. Robson, Weatherall Institute of Molecular Medicine (Presented By: C. Lok, BSc

P- 120

SALICYLALDEHYDE ISONICOTINOYL HYDRAZONE (SIH) AS A CARDIOPROTECTANT
AGAINST DAUNORUBICIN-INDUCED CARDIOTOXICITY IN RABBITS.

M. Sterba, MSc, O. Popelova, MSc, T. Simunek, PharmD, PhD, M. Adamcova, MD, PhD, Y. Mazurova, MD, PhD, P. Ponka, prof, MD, PhD and V. Gersl, prof, MD, PhD, Faculty of Medicine in Hradec Kralove, Charles University in Prague (Presented By: M. Sterba, MSc)

P- 121

MEASURMENT OF NTA-CHELATABLE IRON AS FREE IRON AND ITS RELATION TO DIQUAT-INDUCED OXIDATIVE STRESS

M. Higuchi, BAgrSci, K. Hamaoka, DVM, S. Watabiki, DVM, M. Kabasawa, K. Orino, DVM, PhD, S. Kobayashi, PhD and K. Watanabe, DVM, PhD, Kitasato University School of Veterinary Medicine and Animal Sciences (Presented By: M. Higuchi, BAgrSci)

P- 122

EFFECT OF MODIFIED IRON SUPPLEMENTATION ON OXIDATIVE DNA DAMAGE AND DNA REPAIR IN NEWBORN PIGLETS

R. Starzynski, PhD, B. Tudek, R. Olinski, A. Winczur, R. Rozalski, P. Kowalczyk, T. Dziaman, E. Smuda, M. Gralak, R. Zabielski and P. Lipinski, Institute og genetics and Animal Breeding Polish Academy of Sciences (Presented By: R. Starzynski, PhD)

P- 123

THE HEMOGLOBIN DEFERRALRATE OF VOLUNTARY BLOOD DONORSAND IRON DEFICIENCY IN JAPAN

T. Uchida, MD, Kagawa Blood Center, Japanese Red Cross (Presented By: T. Uchida, MD)

P- 124

SUSTAINED REDUCTION OF BASAL LABILE PLASMA IRON (LPI) AFTER PROLONGED THERAPY WITH DEFERASIROX IN THALASSEMIA PATIENTS.

G. Zanninelli, MD, PhD, F. Sorrentino, MD, R. Iazzoni, PhD, W. Breuer, PhD, I. Cabanthick, MD, PhD and P. Cianciulli, MD, Ospedale S’Eugenio, Unita’ Day Hospital Talassemici (Presented By: G. Zanninelli, MD, PhD)

P- 125

EXPLORING THE COST-EFFECTIVENESS OF COMMUNITY GENETIC SCREENING FOR HEREDITARY HAEMOCHROMATOSIS: A LIFE-TIME SIMULATION USING A MARKOV MODEL

R. Anderson, PhD, K. Allen, PhD, A. Nisselle, PhD, L. Gurrin, PhD, J. Hall, PhD, L. Powell, PhD and M. Delatycki, PhD, Peninsula Medical School, University of Exeter (Presented By: R. Anderson, PhD)

P- 126

LONG-TERM OUTCOME OF IRON-INDUCED CARDIAC DISEASE IN PATIENTS WITH THALASSEMIA MAJOR TREATED WITH COMBINED DFP/DFO OR DFO ALONE: INTERIM REPORT.

M. Lai, MD, S. Vacquer, MD, A. Pepe, MD, A. Maggio, MD, M. Carta, MD, P. Cianciulli, MD, A. Mandas, MD, P. Bina, MD, F. Sau, MD and R. Grady, PhD, Dept.Internal Medicine, Adult Thalassemic Center/University of Cagliari (Presented By: M. Lai, MD)

P- 127

VALIDITY OF SELF-REPORTED SYMPTOMS IN A LARGE GROUP OF SWISS PATIENTS SUSPECTED FOR IRON DEFICIENCY WITH OR WITHOUT ANEMIA

P. Nielsen, PhD, MD, A. Burki, MD, G. Burkard and G. Walosek, PhD, Institute of Molecular Cell Biology (Presented By: P. Nielsen, PhD, MD)

P- 128

IN VIVO ROLES OF THE IRON REGULATORY PROTEINS (IRP)-1 AND -2 IN ASEPTIC LOCAL INFLAMMATION

L. Viatte, PhD, H. Grone, Pr, MD, B. Galy, PhD and M. Hentze, Pr, MD, European Molecular Biology Laboratory (Presented By: L. Viatte, PhD)

P- 129

EXPRESSION OF THE SUBGENOMIC HEPATITIS C VIRUS REPLICON ALTERS IRON HOMEOSTASIS IN HUH7 CELLS

C. Fillebeen, M. Muckenthaler, B. Andriopoulos, M. Bisaillon, Z. Mounir, M. Hentze, A. Koromilas and K. Pantopoulos, Lady Davis Institute for Medical Research (Presented By: K.

P- 130

DOES IRON PLAY A ROLE IN THE PATHOGENESIS AND PHENOTYPE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CIRRHOSIS

R. Ryan, BMBS, FRACP, L. Fletcher, BSc, PhD, D. Jones, RN, K. Stuart, MBBS, PhD, FRACP and D. Crawford, MD, FRACP, Princess Alexandra Hospital (Presented By: R. Ryan, BMBS, FRACP)

P- 131

THE C282Y POLYMORPHIC ALLELE OF HFE IS ASSOCIATED WITH TEMOZOLOMIDE AND IRRADIATION RESISTANCE IN BRAIN TUMOR CELL LINES

S. Lee, PhD, B. Slagle-Webb, BA, R. Geguchadze, PhD, J. Sheehan, MD and J. Connor, PhD, Pennsylvania State University (Presented By: S. Lee, PhD)

P- 132

TRACKING THE FATE OF IRON IN EARLY DEVELOPMENT OF HUMAN BLOOD FLUKES

M. Jones, B Sc PhD, A. Glanfield, B Sc Hons, G. Gobert, B Sc PhD and D. McManus, PhD DSc, Queensland Institute of Medical Research (Presented By: M. Jones, B Sc PhD)

P- 133

ANALYSIS OF NICOTIANAMINE METAL COMPLEXES BY ELECTROSPRAY-MASS SPECTROMETRY

R. Rellan-Alvarez, A. Alvarez-Fernandez, J. Abadia, Department of Plant Nutrition, Experimental Station Aula Dei-CSIC (Presented By: R. Rellan-Alvarez)

P- 134

SYNECHOCYSTIS DRGA PROTEIN FUNCTIONING AS NITROREDUCTASE AND FERRIC REDUCTASE IS CAPABLE OF CATALYZING FENTON REACTION

K. Takeda, PhD, M. Iizuka, MSc, H. Tajima, BSc, J. Sato, MSc, T. Watanabe, PhD, J. Nakagawa, PhD, M. Abo, PhD, E. Yoshimura, PhD, S. Kawasaki, PhD and Y. Niimura, PhD, Department of Bio-science, Tokyo University of Agriculture (Presented By: K. Takeda, PhD)

P- 135

YQJH A NOVEL CYTOPOLASMIC SIDEROPHORE REDUCTASE FOUND IN ESCHERICIA COLI

M. Armour, BSc MSc, M. Cartron, PhD, S. Mitchell, PhD, V. Bamford, PhD, K. Watson, PhD and S. Andrews, PhD, University of Reading (Presented By: M. Armour, BSc MSc)

P- 136

PERTURBATION OF APP PROTEOLYTIC PROCESSING IN AN IN VITRO MODEL OF HEME DEFICIENCY AND MITOCHONDRIA DECAY.

L. Benerini Gatta, M. Poli, R. Verardi, p. arosio and D. Finazzi, university of brescia (Presented By: p. arosio)

P- 137

OMEPRAZOLE DECREASES DUODENAL IRON ABSORPTION VIA INHIBITION OF DMT-1 FUNCTION

S. Mair, S. Ludwiczek, M. Muckenthaler, H. Schwelberger, I. Theurl, H. Weiss, M. Hentze, M. Ritter and G. Weiss, MD, Medical University Innsbruck , Department of Internal Medicine (Presented By: G. Weiss, MD)

P- 138

HANDLING OF ERYTHROCYTE-BOUND 59FE IN MURINE 59FE-DISTRIBUTION STUDIES

K. Schuemann, Prof Dr and B. Szegner, Central Institute for Nutrtition and Food Sciences (Presented By: K. Schuemann, Prof Dr)

P- 139

IRON DEPENDENT CHANGES OF GENE EXPRESSION IN TRICHOMONAS VAGINALIS REVEALED BY MICROARRAYS ANALYSIS

L. Bardonova, MS, M. Basler, PhD, L. Horvathova, MS, P. Tang, PhD, J. Shin, PhD and J. Tachezy, PhD, Department of Parasitology, Faculty of Science, Charles University (Presented By: L. Bardonova, MS)