Program-Monday, April 02, 2007 -1th day

Monday, April 02, 2007

08:30 am – 09:00 am

Opening Ceremony
Location: Hall I (Room A)
INVITED LECTURE – 1 (Co-Chairs: Yutaka Kohgo, Elizabeth Theil)
09:00 am – 09:45 am
IL-02: POSTTRANSLATIONAL PROCESSING OF HEPCIDIN IN HUMAN HEPATOCYTES IS MEDIATED BY A FURIN-TYPE PROHORMONE CONVERTASE
T. Ganz, PhD, MD and E. Valore, MS, Depts. of Medicine and Pathology, David Geffen School of Medicine, UCLA (Presented By: T. Ganz, PhD, MD)
10:30 am – 11:00 am
Break
INVITED LECTURE – 2 (Co-Chairs: Graca Porto, Prem Ponka)
11:00 am – 11:30 am
IL-03: BMP/Hemojuvelin
Herbert Y. Lin, MD, PhD
11:30 am – 12:00 am
IL-04: eALA, Sideroblastic Anemia
Masayuki Yamamoto, MD
12:00 am – 01:30 pm
Lunch
01:30 pm – 04:10 pm
NOVARTIS SYMPOSIUM: IRON LOADING AND ITS CLINICAL IMPLICATIONS (Co-Chairs: Antonello Pietrangelo, Chaim Hershko)
01:30 pm – 01:35 pm
Welcome and Introductions
Antonello Pietrangelo, MD, PhD
01:35 pm – 02:05 pm
Mechanism of Iron Overloading and Toxicity
Greg Anderson, BSc, MSc, PhD
02:05 pm – 02:35 pm
Imaging in the Diagnosis and Management of Transfusion Iron Overload
J. Wood
02:35 pm – 03:05 pm
Treatment and Management of Transfusion Iron Overload
John Porter
03:05 pm – 03:35 pm
Management of Genetic Hemachromatosis
Pierre Brissot, MD
03:35 pm – 04:05 pm
Iron Chelation Beyond Transfusion Iron Overload
Antonello Pietrangelo, MD, PhD
04:05 pm – 04:10 pm
Closing Remarks
Chaim Hershko, MD
04:15 pm – 05:15 pm
EVENING SEMINAR (Chairs: Teiryo Maeda) co-sponsored by Kirin Brewery Co., Ltd.
04:15 pm – 04:45 pm
Rice Genome Information as a Basic Tool in Modern Plant Biology
Takuji Sasaki, Vice President, National Institute of Agrobiological Sciences (NIAS)
04:45 pm -05:15 pm
Exploring iron regulatory networks: integration of biocomputational,biochemical and genomic approaches
Matthias Hentze
01:30 pm – 02:45 pm
Concurrent Session 1: Non-Vertebrate, Immunology (Co-Chairs: Caroline Philpott, Koji Nakayama)
Location: Hall II (Room C-1)
01:30 pm
O-01: IDENTIFICATION OF UGA3 AS AN IRON-REGULATED TRANSCRIPTION FACTOR CONTROLLING THE ACTIVITY OF THE GABA SHUNT IN SACCHAROMYCES CEREVISIAE
C. Philpott and B. Mukhopadhyay, Liver Diseases Branch, NIDDK, NIH (Presented By: C. Philpott)
01:45 pm
O-02: IRON HOMEOSTASIS IN ARABIDOPSIS: VACUOLES AND BEYOND
S. Kim, T. Punshon, A. Lanzirotti, L. Li, J. Kaplan and M. Guerinot, Dartmouth College (Presented By: S. Kim)
02:00 pm
O-03: CLONING OF A NOVEL GLUTATHIONE TRANSPORTER, OSGTL1 FROM RICE
K. BASHIR, MPhil, Y. Ishimaru, PhD, T. Aoyama, S. Nagasaka, PhD, M. Takahashi, PhD, H. Nakanishi, PhD, S. Mori, PhD and N. Nishizawa, PhD, The University of Tokyo (Presented By: K. BASHIR, MPhil)
02:15 pm
O-04: KNOCKOUT OF FRATAXIN GENE CAUSES EMBRYO LETHALITY IN ARABIDOPSIS
I. Murgia, PhD, V. Vazzola, PhD student, A. Losa, PhD and C. Soave, Prof, University Milano (Presented By: I. Murgia, PhD)
02:30 pm
O-05: IDENTIFICATION OF A SURFACE-MEDIATED PATHWAY FOR IRON UPTAKE IN THE PARASITIC TREMATODE SCHISTOSOMA MANSONI
A. Glanfield, BSc (Hons), D. Smyth, PhD, D. McManus, PhD, DSc and M. Jones, PhD,Queensland Institute of Medical Research (Presented By: A. Glanfield, BSc (Hons))
02:45 pm – 04:00 pm
Concurrent Session 2: Iron Transport, Storage (1) (Co-Chairs: Maria Linder, Masahiko Akita)
Location: Hall II (Room C-1)
02:45 pm
O-06: FERRITIN-MEDIATED IRON TRANSPORT VIA TIM-2 IN MOUSE KIDNEY CELLS
S. Torti, PhD, J. Han, PhD, W. Seaman, PhD and F. Torti, MD, Wake Forest University Health Sciences (Presented By: S. Torti, PhD)
03:00 pm
O-07: NEW EVIDENCES FOR THE INVOLVEMENT OF PKCZ PATHWAY IN RESPONSE TO FERRITIN IN HEPATIC STELLATE CELLS USING SHRNA COUPLED TO BACULOVIRUS DELIVERY SYSTEM
M. Philippe, Dr, R. Ruddell, Dr, R. Bing and G. Ramm, assoc Prof, QIMR hepatic fibrosis group (Presented By: M. Philippe, Dr)
03:15 pm
O-08: A FLUORESCENT METAL-SENSOR STUDY PROVIDING EVIDENCE FOR IRON TRANSPORT IN INTESTINAL EPITHELIAL CELLS BY TRANSCYTOSIS.
Y. Ma, MD, PhD, Y. Okazaki, MD, PhD, M. Yeh, MS, K. Yeh, PhD and J. Glass, MD, Feist-Weiller Cancer Center, LSUHSC (Presented By: Y. Okazaki, MD, PhD)
03:30 pm
O-09: SUSTAINED HYDROGEN PEROXIDE INDUCES IRON UPTAKE BY TRANSFERRIN RECEPTOR-1 INDEPENDENT OF THE IRP/IRE NETWORK
B. Andriopoulos, S. Hegedsch, J. Mangin, A. Welker, H. Riedel, U. Hebling, J. Wang, K. Pantopoulos and S. Mueller, Lady Davis Institute for Medical Research (Presented By: K. Pantopoulos)
03:45 pm
O-10: HYPOFERREMIA BUT NO CHANGE IN INTESTINAL IRON TRANSPORT IN MICE FOLLOWING EXPOSURE TO HEPCIDIN
M. Mascarenhas, BSc, T. Chaston, PhD, S. Srai, PhD and P. Sharp, PhD, King’s College London (Presented By: T. Chaston, PhD)
01:30 pm – 02:45 pm
Concurrent Session 3: IRE/IRP (Co-Chairs: Kostas Pantapoulos, Koichi Orino)
Location: Hall III (Room C-2)
01:30 pm
O-11: FUNCTION OF THE IRP/IRE REGULATORY NETWORK IN THE DUODENUM
B. Galy, PhD, D. Ferring-Appel, StaatlGepruft, M. Sanchez, PhD, M. Muckenthaler, PhD, H. Grne, PhD and M. Hentze, MD, European Molecular Biology Laboratory (Presented By: B. Galy, PhD)
01:45 pm
O-12: TISSUE-SPECIFIC FUNCTIONS OF IRON REGULATORY PROTEIN (IRP)-2 IN VIVO
D. Ferring-Appel, B. Galy, PhD and M. Hentze, MD, European Molecular Biology Laboratory (Presented By: D. Ferring-Appel)
02:00 pm
O-13: NEW DEVELOPMENTS IN THE BIOCHEMISTRY OF IRON REGULATORY PROTEINS
J. Moulis, Dr, C. Dycke, PhD, A. Martelli, PhD and E. Rousselet, MSc, CEA-Grenoble (Presented by: J. Moulis, Dr)
02:15 pm
O-14: CONTROL OF IRON REGULATORY PROTEIN 1 BY PHOSPHORYLATION AND PROTEIN DEGRADATION
R. Eisenstein, PhD, A. Vasanthakumar, MS, S. Anderson, MS, DVM and S. Clarke, PhD, University of Wisconsin (Presented By: R. Eisenstein, PhD)
02:30 pm
O-15: IRE-DEPENDENT, DIFFERENTIAL REGULATION OF FERRITIN H AND FERRITIN L MRNA
R. Leipuviene, PhD, J. Long, PhD, Z. Jenkins, PhD and E. Theil, PhD, CHORI and UC-Berkeley (Presented By: E. Theil, PhD)
02:45 pm – 04:00 pm
Concurrent Session 4: FeS, HO-1 (Co-Chairs: Sonia Levi, Masayoshi Kobune)
Location: Hall III (Room C-2)
02:45 pm
O-16: MOBILIZATION OF INTRACELLULAR IRON FOR BIOGENESIS OF IRON-SULFUR
H. Ding, PhD, J. Bitoun, Bsc and J. Yang, Ms, Louisiana State University (Presented By: H. Ding, PhD)
03:00 pm
O-17: DOWN-REGULATION OF COMPONENTS OF THE FE-S CLUSTER ASSEMBLY MACHINERY IN INFLAMMATORY MACROPHAGES
C. Bouton, PhD, F. CANAL, PHD student, C. FOSSET, PhD, M. CHAUVEAU, technician and J. DRAPIER, PhD, Institut de Chimie des Substances Naturelles-CNRS (Presented By: C. Bouton, PhD)
03:15 pm
O-18: THE ROLE OF MITOCHONDRIAL AND CYTOSOLIC IRON-SULFUR CLUSTER BIOGENESIS IN MAINTAINENCE OF MAMMALIAN IRON HOMEOSTASIS
W. Tong, PhD, K. Li, PhD, H. Uhrigshardt, PhD and T. Rouault, MD, National Institute of Child Health and Human Development (Presented By: W. Tong, PhD)
03:30 pm
O-19: HEME AND IRON HOMEOSTASIS ARE LINKED WITH THAT OF COPPER VIA THE HEMOPEXIN-HEME OXYGENASE-1 AXIS
K. Rish, MS, R. Helston, PhD and A. Smith, PhD, University of Missouri-Kansas City (PresentedBy: A. Smith, PhD)
03:45 pm
O-20: ANALYIS OF PROTEINS INVOLVED IN MAMMALIAN FE/S BIOSYNTHESIS BY SIRNA SILENCING
P. Cavadini, PhD, M. Poli, PhD, S. Luscieti, PhD and P. Arosio, Dipartimento Materno Infantile e Tecnologie Biomediche, University of Brescia (Presented By: P. Arosio)

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