Program-Thursday, April 05, 2007 -4th day

Thursday, April 05, 2007

INVITED LECTURE – 8 (Co-Chairs: Carole Beaumont, Naoko Nishizawa)

08:30 am – 09:00 am

IL-15: IRON UPTAKE AND STORAGE IN PLANTS

J. Briat, PhD, N. Arnaud, Graduate student, F. Cellier, PhD, C. Curie, PhD, F. Gaymard, PhD, K. Ravet, Graduate student, M. Sgula, Graduate student and G. Vert, PhD, CNRS (Presented By: J. Briat, PhD)

09:00 am – 09:30 am

IL-16: INFECTION REVIEW

Guenter Weiss, MD

09:30 am – 10:00 am

Break

PLENARY SESSION – 2 (Co-Chairs: Caroline Enns, Satoshi Mori)

10:00 am – 10:20 am

PL-04: TRANSPORTERS INVOLVED IN THE UPTAKE AND TRANSLOCATION OF IRON IN PLANTS

N. Nishizawa, Ph D, M. Takahashi, Ph D, H. Nakanishi, Ph D and S. Mori, Ph D, Graduate Schoolof Agricultural and Life Sciences, The University of Tokyo (Presented By: N. Nishizawa, Ph D)

10:20 am – 10:40 am

PL-05: BIOSYNTHESIS OF MAGNETITE IN MAGNETOSOMES AND THE ROLE OF FERRITIN IN M. GRYPHISWALDENSE

D. Faivre, PhD, L. Boettger, DiplPhys, D. Schueler, Prof Dr and B. Matzanke, PhD; DiplChem, University of Luebeck (Presented By: B. Matzanke, PhD; DiplChem

10:40 am – 11:00 am

PL-06: FERRITIN INHIBITS CLEAVAGE OF HIGH MOLECULAR WEIGHT KININOGEN BY ELASTASE AND MAST CELL TRYPTASE

L. Coffman, J. Brown, D. Johnson, N. Parthasarathy, R. D’Agostino, Jr., W. Muller-Esterl, F. Torti, MD and S. Torti, PhD, Wake Forest University (Presented By: F. Torti, MD)

PLENARY SESSION – 3 (Co-Chairs: L.C. Khn, Kiyotaka Watanabe)

11:00 am – 11:20 am

O-61: ALTERED ARACHIDONIC ACID METABOLISM IN THE INTESTINE OF IRON AND IRON/COPPER-DEFICIENT RATS: STRONG INDUCTION OF 12-LIPOXYGENASE

J. Collins, PhD, R. Browne, PhD, M. Garrick, PhD, L. Garrick, PhD and Z. Hu, PhD, University at Buffalo, SUNY (Presented By: J. Collins, PhD)

11:20 am – 11:40 am

PL-08: LOCATION OF A PUTATIVE GENE CONTRIBUTING TO THE SETTING OF CD8+ T LYMPHOCYTES: A MODIFIER OF HEREDITARY HEMOCHROMATOSIS EXPRESSION

J. Vieira, PhD, C. S Cardoso, PhD, J. Pinto, PhD, K. Patil, P. Bradzil, PhD, E. Cruz, MD,PhD, C.Mascarenhas, BsC, R. Lacerda, A. Gartner, MsC, S. Almeida, BsC, H. Alves, MD and G. Porto, MD,PhD, IBMC, Institute for Molecular and Cellular Biology (Presented By: G. Porto, MD,PhD)

11:40 am – 12:00 pm

PL-09: INVESTIGATING THE DEPENDENCY OF HIV-1 REPLICATION IN MACROPHAGES ON CELLULAR IRON

H. Drakesmith, BA, PhD, L. Eddowes, MChem and A. Townsend, MBBSc, Molecular Immunology Group, Weatherall Institute of Molecular Medicine (Presented By: H. Drakesmith, BA, PhD)

10:00 am – 11:00 pm

Concurrent Session 11: Iron Transport and Storage (2) (Co-Chairs: Elizabeth Leibold, Hiroshi Kawabata)

Location: Hall II (Room C-1)

10:00 am

O-49: EXPRESSION OF ZIP14, DMT1, AND TFR1 IN HFE-/- AND HYPOTRANSFERRINEMIC MICE

H. Nam, MS, H. Gunshin, PhD, J. Liuzzi, PhD and M. Knutson, PhD, University of Florida (Presented By: M. Knutson, PhD)

10:15 am

O-50: BLUNTED HEPCIDIN RESPONSE TO ORAL IRON CHALLENGE IN HEMOCHROMATOSIS

A. Piperno, D. Girelli, E. Nemeth, P. Trombini, C. Bozzini, E. Poggiali, T. Ganz and C. Camaschella, MD, Vita-Salute San Raffaele University (Presented By: C. Camaschella, MD)

10:30 am

O-51: IRON UPTAKE BY TRANSFERRIN RECEPTOR 1 IS REGULATED BY HFE IN HEPATOCYTES

A. Chua, PhD, C. Herbison, BSc (Hons), S. Drake, BSc (Hons), R. Graham, PhD, J. Olynyk, MD and D. Trinder, PhD, The University of Western Australia (Presented By: A. Chua, PhD)

10:45 am

O-52: TRANSCRIPTIONAL MODULATION OF TRANSFERRIN RECEPTOR EXPRESSION BY INFLAMMATORY AND ANTI-INFLAMMATORY SIGNALS IN MACROPHAGES: ROLE OF HIF-1 AND NF-KB

G. Cairo, PhD, C. De Ponti, PhD, E. Gammella, PhD, V. Beretta, PhD, S. Recalcati, MD, PhD and L. Tacchini, PhD, University of Milan (Presented By: G. Cairo, PhD)

11:00 am – 12:00 pm

Concurrent Session 12: Iron Transport and Storage (3) (Co-Chairs: Abraham Konijn, Hirofumi Yajima)

Location: Hall II (Room C-1)

11:00 am

O-53: CHARACTERIZATION OF TRANSFERRIN RECEPTOR 2 ALPHA EXPRESSED IN CHINESE HAMSTER OVARY CELLS

K. Ikuta, MD, PhD, J. Jimbo, MD, T. Hosoki, MD, M. Shindo, MD, PhD, K. Sato, MD, PhD, Y. Torimoto, MD, PhD, O. Zak, PhD, P. Aisen, MD, PhD and Y. Kohgo, MD, PhD, Asahikawa Medical College (Presented By: K. Ikuta, MD, PhD)

11:15 am

O-54: PEPTIDES THAT BIND FERRITIN PORES AND FACILITATE IRON RELEASE/CHELATION

X. Liu, PhD and E. Theil, PhD, CHORI and UC-Berkeley (Presented By: E. Theil, PhD)

11:30 am

O-55: BOTH IRON DEFICIENT AND BELGRADE (B/B) RATS SHOW SIMILAR CHANGES IN EXPRESSION OF IRON- RELATED GENES IN THE DUODENAL CYPT-VILLUS AXIS

K. Yeh, PhD, M. Yeh, MS and J. Glass, MD, LSU Health Science Center (Presented By: K. Yeh,PhD)

11:45 am

O-56: SOLUBLE HEMOJUVELIN IS A POSITIVE REGULATOR OF HEPCIDIN EXPRESSION

B. Andriopoulos, D. Palaiologou, C. Fillebeen, A. Daba, M. Robinson, A. Hadjis, G. Papanikolaou and K. Pantopoulos, Lady Davis Institute for Medical Research (Presented By: K. Pantopoulos)

10:00 am – 11:00 am

Concurrent Session 13: Treatment, Iron Marker (Co-Chairs: Grant Ramm, Yoshihiro Torimoto)

Location: Hall III (Room C-2)

10:00 am

O-67: SHUTTLING IRON BETWEEN CELL COMPARTMENTS . A NEW THERAPEUTIC ROLE FOR IRON CHELATORS

Y. Sohn, MSc, W. Breuer, PhD, A. Munnich, MD PhD and I. Cabantchik, MD PhD, Hebrew University of Jerusalem (Presented By: I. Cabantchik, MD PhD)

10:15 am

O-68: DEFERASIROX(EXJADE, ICL670) EFFCIENTLY REMOVES LABILE PLASMA IRON AS COMPARED TO DESFERIOXAMINE AND DEFERIPRONE: A 24-HOUR MONITORING STUDY IN THALASSEMIA PATIENTS.

G. Zanninelli, MD, PhD, F. Sorrentino, MD, R. Iazzoni, PhD, R. Marzano, MD, W. Breuer, PhD, I. Cabanthick, MD, PhD and P. Cianciulli, MD, Ospedale S’Eugenio, Unita’ DAy Hospital Talassemici (Presented By: G. Zanninelli, MD, PhD)

10:30 am

O-69: HEALTHIRON: A LONGITUDINAL POPULATION STUDY DEFINING THE BURDEN OF DISEASE IN HFE-ASSOCIATED HEREDITARY HEMOCHROMATOSIS

K. Allen, MBBS BMedSci FRACP PhD, L. Gurrin, PhD, N. Osborne, PhD, C. Constantine, PhD, M. Delatycki, MBBS PhD, A. Nicoll, MBBS, C. McLaren, PhD, M. Bahlo, PhD, A. Fletcher, MEpi, A. Nisselle, BSc, S. Forrest, DPhil, C. Vulpe, PhD MD, G. Anderson, PhD, G. Giles, PhD and D. English, PhD, Murdoch Childrens Research Institute and Dept of Gastroenterology (Presented By: K. Allen, MBBS BMedSci FRACP PhD)

10:45 am

O-70: IRON MEASURES AT BASELINE AND FOLLOW-UP FROM A LONGITUDINAL STUDY OF MODIFIERS OF HEREDITARY HAEMOCHROMATOSIS: THE HEALTHIRON STUDY.

L. Gurrin, BSc (Hons) PhD, K. Allen, MBBS, N. Osborne, PhD, C. Constantine, PhD, M. Delatycki, MBBS, A. Nisselle, BSc, A. Fletcher, MEpi, C. McLaren, PhD, G. Anderson, PhD, D. English, PhD, J. Hopper, PhD, G. Giles, PhD, J. Olynyk, MBBS, A. Nicoll, MBBS and L. Powell, MBBS, University of Melbourne (Presented By: L. Gurrin, BSc (Hons) PhD)

11:00 am – 12:00 pm

Concurrent Session 14: Anemia and others (Co-Chairs: Iain MacDougall, Tatsumi Uchida)

Location: Hall III (Room C-2)

11:00 am

PL-17: THE HUMAN COUNTERPART OF ZEBRAFISH SHIRAZ HAS MICROCYTIC ANEMIA AND IRON OVERLOAD

C. Camaschella, MD, A. Campanella, L. Defalco, L. Boschetto, R. Merlini, MD, L. Silvestri, S. Levi and A. Iolascon, MD, Vita-Salute San Raffaele University (Presented By: C. Camaschella, MD)

11:15 am

O-72: MULTIPLE FERROXIDASES IN MOUSE AND HUMAN PLASMA

M. Linder, PhD, L. Gray, BS, T. Kidane, MS, A. Nguyen, undergraduate, S. Akagi, undergraduate,K. Petrasek, undergraduate, Y. Chu, BS, T. Pham, undergraduate, A. Cabrera, BS, K. Kantardjieff, PhD and A. Mason, PhD, California State University (Presented By: M. Linder, PhD)

11:30 am

O-73: C-REACTIVE PROTEIN (CRP) AND BETA2 MICROGLOBULIN (BMG) ACCELERATED THE IRON SEQUESTRATION IN HUMAN MONOCYTIC CELL LINES: LINKAGE TO ANEMIA OF CHRONIC DISEASE

M. Nanami, MD, PhD, R. Moriguchi, MD, A. Kida, MD, K. Ito, MD, S. Yamamoto, MD, Y. Otaki, MD, PhD, Y. Hasuike, MD, PhD, T. Kuragano, MD, PhD, M. Izumi, MD and T. Nakanishi, MD, Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine (Presented By: M. Nanami, MD, PhD)

11:45 am

O-74: ANGIOTENSIN II INDUCES UPREGULATION OF HEME OXYGENASE-1 AND DEPOSITION OF IRON IN THE KIDNEY OF RAT — POSSIBLE LINK TO OXIDATIVE STRESS AND CELLULAR APOPTOSIS

N. Ishizaka, T. Aizawa, MD, K. Saito, MD, K. Furuta, G. Matsuzaki, MD and R. Nagai, MD, University of Tokyo Graduate School of Medicine (Presented By: N. Ishizaka)

12:00 pm – 01:30 pm

Lunch

PLENARY SESSION – 4 (Co-Chairs: Tomas Ganz, Ioav Cabantchik)

01:30 pm – 01:50 pm

PL-10: FERROPORTIN RESIDUE C326 IS CRITICAL FOR ITS INTERACTION WITH HEPCIDIN

A. Fernandes, PhD, E. Nemeth, PhD and T. Ganz, PhD, MD, David Geffen School of Medicine, UCLA (Presented By: E. Nemeth, PhD)

01:50 pm – 02:10 pm

PL-11: ZYKLOPEN, A NEW MEMBER OF THE MULTI-COPPER FERROXIDASE FAMILY, IS EXPRESSED IN MULTIPLE TISSUES.

Y. Kuo, PhD, Z. Attieh, PhD, H. Chen, PhD, B. Syed, PhD, J. Gitschier, PhD, H. McArdle, PhD and C. Vulpe, MD, PhD, Department of Nutritional Sciences and Toxicology, University of California at Berkeley (Presented By: C. Vulpe, MD, PhD)

02:10 pm – 02:30 pm

PL-12: DROSOPHILA AS A MODEL SYSTEM TO STUDY IRON METABOLISM

F. Missirlis, PhD and T. Rouault, MD, National Institute of Child Health and Human Development(Presented By: F. Missirlis, PhD)

02:30 pm – 02:50 pm

PL-13: IDENTIFICATION OF GENES FACILITATING IRON STORAGE IN FERRITIN

C. Philpott and H. Shi, Liver Diseases Branch, NIDDK, NIH (Presented By: C. Philpott

PLENARY SESSION – 5 (Co-Chairs: Gordon McLaren, V.N. Subramaniam)

02:50 pm – 03:10 pm

PL-14: FERROPORTIN: MEMBRANE TOPOLOGY AND CHARACTERISATION OF MUTATIONS

D. Wallace, BSc (Hons), PhD and V. Subramaniam, MSc, PhD, Queensland Institute of Medical Research (Presented By: D. Wallace, BSc (Hons), PhD)

03:10 pm – 03:30 pm

PL-15: HEPCIDIN-INDEPENDENT REGULATION OF FERROPORTIN: A NOVEL ROLE FOR CERULOPLASMIN IN IRON EXPORT

I. De Domenico, PhD, D. Ward, PhD, M. Bonaccorsi di patti, PhD, S. Jeong, BS, S. David, PhD,G. Musci, BS and J. Kaplan, PhD, (Presented By: I. De Domenico, PhD)

03:30 pm – 03:50 pm

PL-16: ROLES OF IRON REGULATORY PROTEINS 1 AND 2 IN MAMMALIAN IRON METABOLISM

M. Ghosh, PhD, S. Cooperman, MD PhD, D. Zhang, PhD, W. Tong, PhD, H. Ollivierre Wilson, E.Meyron-Holtz, PhD, J. Mitchell, PhD and T. Rouault, MD, National Institutes of Health (Presented By: T. Rouault, MD)

04:00 pm – 05:00 pm

Evening Seminar (Chair: Pauline Harrison) co-sponsored by Eisai Co. Ltd.

04:00 pm – 04:30 pm

Apoptosis/necrosis and iron

Yoshiro Niitsu

04:30 pm – 05:00 pm

ES-02: PATHOGENESIS AND MANAGEMENT OF REFRACTORY IRON DEFICIENCY ANEMIA: ROLE OF H. PYLORI AND AUTOIMMUNE GASTRITIS

C. Hershko, MD, M. Ianculovich, PhD and M. Souroujon, PhD, Department of Hematology, Shaare Zedek Medical Center, (Presented By: C. Hershko, MD)

01:30 pm – 02:45 pm

Concurrent Session 15: Animal Model (Co-Chairs: Richard Eisenstein, Shinya Toyokuni)

Location: Hall II (Room C-1)

01:30 pm

O-57: MODIFICATION OF THE EXPRESSION OF HAMP AND HFE IN BETA-THALASSEMIA AND HEMOCHROMATOS

P. Ramos, Bachelor, S. Gardenghi, PhD, A. Follenzi, PhD, J. Pinto, PhD, F. Marongiu, PhD, E. Guy, Bachelor, L. Breda, PhD, T. Ganz, PhD, E. Nemeth, PhD, P. Giardina, MD, R. Grady, MD, M. de Sousa, MD, PhD and S. Rivella, PhD, Weill Medical College of Cornell University (Presented By: S. Rivella, PhD)

01:45 pm

O-58: IRON UPTAKE FROM PLASMA TRANSFERRIN IN A TFR2 MUTANT MOUSE MODEL OF HEREDITARY HAEMOCHROMATOSIS TYPE 3

D. Trinder, BSc PhD, A. Chua, BSc(Hons) PhD, R. Delima, BSc(Hons), E. Morgan, MBBS PhD DSc, C. Herbison, BSc(Hons), R. Graham, BSc(Hons) PhD, R. Fleming, MD, R. Britton, PhD, B.Bacon, MD and J. Olynyk, MBBS MD, University of Western Australia (Presented By: D. Trinder, BSc, PhD)

2:00 pm

O-59: GENE EXPRESSION PROFILING OF HFE-/- LIVER AND DUODENUM IN TWO MOUSE STRAINS WITH DIVERGENT IRON LOADING SEVERITY: IDENTIFICATION OF POTENTIAL HEMOCHROMATOSIS MODIFIERS AND TRANSCRIPTIONAL REGULATORY TARGETS OF HFE

H. Coppin, PhD, V. Darnaud, Master, M. Bensaid, PhD, S. Fruchon, PhD and M. Roth, MD, Inserm U563 (Presented By: H. Coppin, PhD)

02:15 pm

O-60: LIVER-SPECIFIC DELETION OF THE TRANSFERRIN RECEPTOR 2 GENE IN MICE LEADS TO IRON OVERLOAD

V. Subramaniam, M Sc, PhD, L. Summerville, BSc, GradDip and D. Wallace, BSc (Hons), PhD, Queensland Institute of Medical Research (Presented By: V. Subramaniam, M Sc, PhD)

02:30 pm

PL-07: EXPRESSION OF GENES OF IRON METABOLISM IN HUMAN MACROPHAGE DIFFERENTIATION AND POLARIZED ACTIVATION PROCESSES

G. Cairo, PhD, V. Parazzi, PhD, P. Santambrogio, PhD and S. Recalcati, MD, PhD, University of Milan (Presented By: G. Cairo, PhD)

01:30 pm – 02:30 pm

Concurrent Session 16: Diagnosis, Imaging (Co-Chairs: Tim St. Pierre, Fumiaki Kimura)

Location: Hall III (Room C-2)

01:30 pm

O-75: SIMULTANEOUS MAPPING OF MULTIPLE METALS IN WHOLE HUMAN BRAIN SLICES USINGRAPID SCANNING X-RAY FLUORESCENCE SPECTROSCOPIC IMAGING

B. Popescu, MD, A. Hanson, BSc, M. Kelly, MD, FRCPC, S. Harder, MD, FRCPC, I. Pickering, PhD, G. George, PhD and H. Nichol, PhD, University of Saskatchewan (Presented By: B. Popescu, MD)

01:45 pm

O-76: MRI CHARACTERIZATION OF FERRITIN-LIKE AND HEMOSIDERIN-LIKE IRON

E. Wu, PhD, J. Cheung, BS, A. Chow, BS, J. Jensen, PhD, T. Brown, PhD, W. Au, MD, S. Ha, MD, S. Sheth, MD and G. Brittenham, MD, The University of Hong Kong (Presented By: E. Wu, PhD)

02:00 pm

O-77: DIRECT DETERMINATION OF SERUM HEPCIDIN 25 IS A SENSITIVE SCREENING TEST FOR HEMOCHROMATOSIS

Y. Kaneko, MD, S. Motonishi, BS, N. Tomosugi, MD, H. Hayashi, MD, M. Yano, MD, S. Wakusawa, PhD, T. Ikeda, MD, T. Okada, MD, K. Miyamoto, PhD, K. Hayashi, MD, Y. Katano, MD and H. Goto, MD, Department of Internal Medicine, Graduate School of Medicine, Kanazawa University (Presented By: Y. Kaneko, MD)

02:15 pm

O-78: SNP SELECTION FOR CANDIDATE GENES OF IRON METABOLISM: THE GENETIC MODIFIERS OF HEMOCHROMATOSIS PHENOTYPE (HEALTHIRON) STUDY

C. Constantine, PhD, L. Gurrin, BSc (Hons) PhD, C. McLaren, MS PhD, M. Bahlo, PhD, G. Anderson, PhD, C. Vulpe, PhD MD, F. Sue, DPhil, A. Katie, MBBS PhD and G. Dorota, MBBS NHSc ScD, University of Melbourne (Presented By: L. Gurrin, BSc (Hons) PhD)

02:30 pm – 03:45 pm

Concurrent Session 17: Iron Overload (Co-Chairs: Gordon McLaren, Akio Urabe)

Location: Hall III (Room C-2)

02:30 pm

O-79: CAGED-IRON CHELATRS’ AS POWERFUL PRODRUGS TO PROTECT THE SKIN CELLS AGAINST IRON-MEDIATED LYSOSOMAL DAMAGE AND NECROTIC CELL DEATH

C. Pourzand, DSc, A. Yiakouvaki, PhD, J. Savovic, PhD, A. Al-Qenaei, MPhil and J. Dowden, PhD, Department of Pharmacy (Presented By: C. Pourzand, DSc)

02:45 pm

O-80: IMPACT OF LONG-TERM DEFERASIROX (EXJADE, ICL670) TREATMENT IN MAINTAINING OR REDUCING SERUM FERRITIN LEVELS, AND OUTCOME OF DOSE ADJUSTMENTS

J. Porter, A. Cohen, L. Agaoglu, A. Ganser, M. Cappellini, H. Maseruka, E. Glimm and D. Alberti, University College (Presented By: J. Porter)

03:00 pm

O-81: SERUM LEVELS OF HEPCIDIN 25 IN CHRONIC HEPATITIS C

K. Hayashi, MD, S. Motonishi, BS, N. Tomosugi, MD, H. Hayashi, MD, M. Yano, MD, S. Wakusawa, PhD, Y. Katano, MD, H. Goto, MD and K. Miyamoto, PhD, Nagoya University Graduate School of Medicine (Presented By: K. Hayashi, MD)

3:15 pm

O-82: THE NEGATIVE IMPACT OF IRON OVERLOAD ON MORBIDITY/MORTALITY IN JAPANESE PATIENTS WITH TRANSFUSION-DEPENDENT MYELODYSPLASTIC SYNDROMES AND APLASTIC ANEMIA: A RETROSPECTIVE SURVEY

M. Takatoku, T. Uchiyama, S. Okamoto, Y. Kanakura, K. Sawada, M. Tomonaga, S. Nakao, T. Nakahata, M. Harada, T. Murate and K. Ozawa, Jichi Medical University (Presented By: M. Takatoku)

03:30 pm

O-83: IRON OVERLOAD IN BETA-THALASSEMIA IS CHARACTERIZED BY DOWN REGULATION OF HEPCIDIN AND UP REGULATION OF FERROPORTIN

S. Rivella, PhD, S. Gardenghi, PhD, P. Ramos, L. Breda, PhD, A. Chadburn, MD, G. Rechavi, MD, N. Amariglio, PhD, E. Rachmilewitz, MD, D. Wrighting, PhD, N. Andrews, MD, W. Breuer, PhD, I. Cabantchik, MD, M. de Sousa, MD, P. Giardina, MD and R. Grady, PhD, Weill Medical College of Cornell University (Presented By: S. Rivella, PhD)

02:45 pm – 04:00 pm

Concurrent Session 18: Central Nervous System (Co-Chairs: James Connor, Hiroaki Miyajima)

Location: Hall II (Room C-1)

02:45 pm

O-62: CERULOPLASMIN AND THE IRON-HOMEOSTATIC RESPONSE TO SPINAL CORD INJURY

K. Rathore, B. Kerr, PhD, R. Lopez-Vales, PhD, P. Ponka, PhD/MD and S. David, PhD, Centre for Research In Neuroscience, McGill University Health Center, Montreal (Presented By: K. Rathore)

03:00 pm

O-63: THE ROLE OF IRON IN NEUROFERRITINOPATHIES.

A. Cozzi, PhD, G. Frizzale, PhD, P. Santambrogio, PhD, A. Campanella, PhD, P. Arosio, PhD and S. Levi, PhD, Vita-Salute San Raffaele University and San Raffaele Scientific Institute (Presented By: S. Levi, PhD)

03:15 pm

O-64: A ROLE FOR IRON, CALCIUM AND REACTIVE OXYGEN SPECIES ON HIPPOCAMPAL SYNAPTIC PLASTICITY.

C. Hidalgo, PhD, P. Muoz, PhD and M. Nunez, PhD, Biology, Faculty of Sciences, University of Chile (Presented By: M. Nunez, PhD)

03:30 pm

O-65: MITOCHONDRIAL FERRITIN PROTECTS HELA CELLS AND FRIEDREICH ATAXIA FIBROBLASTS BY LIMITING OXIDATIVE STRESS.

A. Campanella, P. Santambrogio, A. Cozzi, P. Arosio and S. Levi, San Raffaele Scientific Institute (Presented By: A. Campanella)

03:45 pm

O-66: MITOCHONDRIAL FERRITIN EXPRESSION IS LOCALIZED TO NEURONS IN THE PUTAMEN AND SUBSTANTIA NIGRA OF HUMAN BRAINS; ALTERED EXPRESSION IN RESTLESS LEGS SYNDROME

J. Connor, PhD, X. Wang, MD, PhD, P. Arosio, PhD, S. Levi, PhD, R. Allen, PhD and C. Earley, PhD, Pennsylvania State University College of Medicine (Presented By: J. Connor, PhD)